Translational Molecular Imaging and Theranostics Laboratory
TMT Laboratory News
Dr. Chiwoo Oh, Dr. Hanna Jung, and Jiwoo Park¡¯s paper, titled ¡°Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives,¡± has been published in ACS Nano (IF: 16.0).
This review highlights the critical immunological functions of the spleen—the largest lymphoid organ—and explores various strategies for designing spleen-targeting nanoparticles. It introduces the types of spleen-targeted nanomedicines developed to date, key considerations for their design, and their therapeutic applications in diseases such as cancer and autoimmune disorders. Furthermore, the paper emphasizes the importance of omics-based analytical tools, such as spatial transcriptomics, in gaining a deeper and more precise understanding of spleen-targeted immunomodulatory strategies.