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<br/><br/><br/><br/><br/>------- 원본 내용 ---------<br/><br/><br/><img hspace="5" vspace="0" src="/bizdemo54043/component/board/board_6/u_image/72/631776647_acsnano_news.JPG" style="width: 595px; height: 596px;"><br /><br /><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">황지은, 전미연, 박지우, 김홍식, 이수빈, 박해나의 “</span></span></span></span></span></span></span></span></span></span></span></span></span><b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(0, 0, 0);">Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer</span></span></span></span></span></span></span></span></span></span></span></span></span></b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">” 논문이 </span></span></span></span></span></span></span></span></span></span></span></span></span><b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(0, 0, 0);">ACS Nano (IF: 16.1)</span></span></span></span></span></span></span></span></span></span></span></span></span></b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">에 게재되었다.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><br /></span><br /><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">해당 연구에서는 pancreatic ductal adenocarcinoma (PDAC)에서 약물 전달을 제한하는 치밀한 종양 기질 장벽을 극복하기 위해 collagenase 효소가 기능화된 리포좀 기반 나노전달체를 개발하였다. 연구진은 콜라겐 기반 세포외기질을 분해함으로써 종양 조직 내 나노입자의 침투와 약물 분포를 향상시키는 전략을 제시하였으며, 이를 통해 기존 전달 시스템 대비 향상된 항암 효과를 확인하였다. </span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">본 연구는 종양 미세환경의 물리적 장벽을 극복하기 위한 효소 기반 나노약물 전달 전략의 가능성을 제시하며, PDAC와 같은 난치성 종양 치료를 위한 새로운 약물 전달 접근법의 방향성을 제시한다.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><br /><p data-start="57" data-end="294"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">The paper </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><strong data-start="67" data-end="156"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">“<span style="color: rgb(0, 0, 0);">Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer</span>”</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></strong><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> by </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span data-start="160" data-end="247"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">Jee-Eun Hwang, Miyeon Jeon, Jiwoo Park, Hong-Sik Kim, Subin Lee, and Haena Park</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> has been published in </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><strong data-start="270" data-end="293"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(0, 0, 0);">ACS Nano (IF: 16.1)</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></strong><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">.</span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span><br><p data-start="296" data-end="779"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">In this study, the researchers developed a </span></span></span></span></span></span></span></span></span></span></span><span data-start="339" data-end="391"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">collagenase-functionalized liposomal nanocarrier</span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> designed to overcome the dense stromal barrier that limits drug delivery in </span></span></span></span></span></span></span></span></span></span></span><span data-start="468" data-end="511"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">pancreatic ductal adenocarcinoma (PDAC).</span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> By degrading the collagen-rich extracellular matrix, the system enhanced nanoparticle penetration and drug distribution within tumor tissues, resulting in improved anticancer efficacy compared with conventional delivery systems.</span></span></span></span></span></span></span></span></span></span></span><br><p data-start="781" data-end="1020"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">This work highlights the potential of </span></span></span></span></span></span></span></span></span></span></span><span data-start="819" data-end="859"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">enzyme-based nanomedicine strategies</span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> to overcome physical barriers in the tumor microenvironment and suggests a promising drug delivery approach for the treatment of refractory tumors such as PDAC.</span></span></span></span></span></span></span></span></span></span></span><br>
<img hspace="5" vspace="0" src="/bizdemo54043/component/board/board_6/u_image/72/631776647_acsnano_news.JPG" style="width: 595px; height: 596px;"><br /><br /><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">황지은, 전미연, 박지우, 김홍식, 이수빈, 박해나의 “</span></span></span></span></span></span></span></span></span></span></span></span></span><b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(0, 0, 0);">Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer</span></span></span></span></span></span></span></span></span></span></span></span></span></b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">” 논문이 </span></span></span></span></span></span></span></span></span></span></span></span></span><b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(0, 0, 0);">ACS Nano (IF: 16.1)</span></span></span></span></span></span></span></span></span></span></span></span></span></b><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">에 게재되었다.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><br /></span><br /><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">해당 연구에서는 pancreatic ductal adenocarcinoma (PDAC)에서 약물 전달을 제한하는 치밀한 종양 기질 장벽을 극복하기 위해 collagenase 효소가 기능화된 리포좀 기반 나노전달체를 개발하였다. 연구진은 콜라겐 기반 세포외기질을 분해함으로써 종양 조직 내 나노입자의 침투와 약물 분포를 향상시키는 전략을 제시하였으며, 이를 통해 기존 전달 시스템 대비 향상된 항암 효과를 확인하였다. </span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">본 연구는 종양 미세환경의 물리적 장벽을 극복하기 위한 효소 기반 나노약물 전달 전략의 가능성을 제시하며, PDAC와 같은 난치성 종양 치료를 위한 새로운 약물 전달 접근법의 방향성을 제시한다.</span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><br /><p data-start="57" data-end="294"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">The paper </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><strong data-start="67" data-end="156"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">“<span style="color: rgb(0, 0, 0);">Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer</span>”</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></strong><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> by </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span data-start="160" data-end="247"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">Jee-Eun Hwang, Miyeon Jeon, Jiwoo Park, Hong-Sik Kim, Subin Lee, and Haena Park</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> has been published in </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><strong data-start="270" data-end="293"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(0, 0, 0);">ACS Nano (IF: 16.1)</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></strong><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">.</span></span></span></span></span></span></span></span></span></span><br /></span></span></span></span></span><br><p data-start="296" data-end="779"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">In this study, the researchers developed a </span></span></span></span></span></span></span></span></span></span></span><span data-start="339" data-end="391"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">collagenase-functionalized liposomal nanocarrier</span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> designed to overcome the dense stromal barrier that limits drug delivery in </span></span></span></span></span></span></span></span></span></span></span><span data-start="468" data-end="511"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">pancreatic ductal adenocarcinoma (PDAC).</span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> By degrading the collagen-rich extracellular matrix, the system enhanced nanoparticle penetration and drug distribution within tumor tissues, resulting in improved anticancer efficacy compared with conventional delivery systems.</span></span></span></span></span></span></span></span></span></span></span><br><p data-start="781" data-end="1020"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">This work highlights the potential of </span></span></span></span></span></span></span></span></span></span></span><span data-start="819" data-end="859"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);">enzyme-based nanomedicine strategies</span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 10pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: 굴림, Gulim;"><span style="font-family: 바탕, batang;"><span style="font-family: 궁서, Gungsuh;"><span style="font-family: Arial;"><span style="color: rgb(0, 0, 0);"><span style="color: rgb(118, 123, 134);"><span style="color: rgb(70, 70, 70);"> to overcome physical barriers in the tumor microenvironment and suggests a promising drug delivery approach for the treatment of refractory tumors such as PDAC.</span></span></span></span></span></span></span></span></span></span></span><br>
