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Translational Molecular Imaging and Theranostics Laboratory

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TMT Laboratory News

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<br/><br/><br/><br/><br/>------- 원본 내용 ---------<br/><br/><br/><br /><img hspace="5" vspace="0" src="/bizdemo54043/component/board/board_6/u_image/74/1133355903_ED8AB9ED978820EB89B4EC8AA4.png" style="width: 592px; height: 443px;"><br /><br /><br /><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">이소민 학생의 </span></span></span></span></span></span></span></span></span><strong data-start="80" data-end="209" style="font-size: 9pt;"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">“Method for Analyzing Endosomal Escape Efficiency of Drug Delivery Particles”</span></span></span></span></span></span></span></span></span></strong><span style="font-size: 9pt;"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;"> 기술이 미국 특허로 등록되었다.</span></span><br /></span></span></span></span></span></span></span></span><br /><p data-start="229" data-end="437"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">지질나노입자(lipid nanoparticle, LNP), 리포좀 등과 같은 약물전달입자는 세포 내로 유입되는 과정에서 엔도좀(endosome)을 형성한다. 전달된 약물이 효과적으로 기능을 발휘하기 위해서는 입자 또는 탑재 물질이 엔도좀을 탈출하여 세포질에서 작용하거나 핵으로 이동할 수 있어야 하므로, 엔도좀 탈출효율은 약물전달 시스템의 성능을 평가하는 중요한 지표이다.</span></span></span></span></span></span></span></span></span><br><p data-start="439" data-end="659"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">본 특허 기술은 약물전달입자의 엔도좀 탈출효율을 자기공명영상 기반으로 정량적으로 분석하는 방법에 관한 것이다. 구체적으로, 산화철 담지 입자를 섭취한 세포 또는 조직에 자기공명영상 장치를 이용하여 전자기파를 조사하고, 이때 반향되는 자기공명신호(MR signal)를 측정한다. 이후 시간 경과에 따른 자기이완율의 변화율을 분석함으로써 약물전달입자의 엔도좀 탈출효율을 정량적으로 평가할 수 있다.</span></span><br /><br /></span></span></span></span></span></span></span><br><p data-start="661" data-end="785"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">본 기술은 다양한 나노약물전달체의 세포 내 전달 성능을 정량적으로 평가할 수 있는 분석 플랫폼으로서, 향후 LNP, 리포좀 및 기타 나노전달체 기반 치료제 개발 과정에서 중요한 평가 기술로 활용될 수 있을 것으로 기대된다.</span></span></span></span></span></span></span></span></span><br><p data-start="661" data-end="785"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><br /></span></span></span><br><p data-start="787" data-end="982"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">The technology </span></span></span></span></span></span></span></span></span><span data-start="802" data-end="931"><span style="font-weight: bold; font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">“</span></span></span></span></span></span></span></span></span><span data-start="80" data-end="209" style="font-size: 9pt;"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><b><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">Method for Analyzing Endosomal Escape Efficiency of Drug Delivery Particles</span></span></span></span></b></span></span></span></span></span></span><span style="font-weight: bold; font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">”</span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;"> by Somin Lee has been registered as a U.S. patent.</span></span></span></span></span></span></span></span></span><br><p data-start="787" data-end="982"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><br /></span></span></span></span></span></span></span><br><p data-start="984" data-end="1469"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">Drug delivery particles, such as lipid nanoparticles (LNPs) and liposomes, are internalized into cells through the formation of intracellular organelles known as endosomes. For the efficient delivery and biological function of encapsulated materials, the particles or their cargo must escape from endosomes and either act in the cytoplasm or migrate to the nucleus. Therefore, endosomal escape efficiency is a critical parameter for evaluating the performance of drug delivery systems.</span></span></span></span></span></span></span></span></span><br><p data-start="1471" data-end="2015"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">This patented technology provides a quantitative method for analyzing the endosomal escape efficiency of drug delivery particles using magnetic resonance-based measurements. Specifically, cells or tissues that have taken up iron oxide-loaded particles are exposed to electromagnetic waves using a magnetic resonance imaging system, and the reflected magnetic resonance signal is measured. By analyzing changes in the magnetic relaxation rate over time, the endosomal escape efficiency of drug delivery particles can be quantitatively evaluated.</span></span><br /><br /></span></span></span></span></span></span></span><br><p data-start="2017" data-end="2298" data-is-last-node="" data-is-only-node=""><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">This technology offers a quantitative analytical platform for assessing the intracellular delivery performance of various nanomedicine systems and is expected to serve as an important evaluation tool in the development of LNP-, liposome-, and other nanoparticle-based therapeutics.</span></span></span></span></span></span></span></span></span><br> <br /><img hspace="5" vspace="0" src="/bizdemo54043/component/board/board_6/u_image/74/1133355903_ED8AB9ED978820EB89B4EC8AA4.png" style="width: 592px; height: 443px;"><br /><br /><br /><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">이소민 학생의 </span></span></span></span></span></span></span></span></span><strong data-start="80" data-end="209" style="font-size: 9pt;"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">“Method for Analyzing Endosomal Escape Efficiency of Drug Delivery Particles”</span></span></span></span></span></span></span></span></span></strong><span style="font-size: 9pt;"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;"> 기술이 미국 특허로 등록되었다.</span></span><br /></span></span></span></span></span></span></span></span><br /><p data-start="229" data-end="437"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">지질나노입자(lipid nanoparticle, LNP), 리포좀 등과 같은 약물전달입자는 세포 내로 유입되는 과정에서 엔도좀(endosome)을 형성한다. 전달된 약물이 효과적으로 기능을 발휘하기 위해서는 입자 또는 탑재 물질이 엔도좀을 탈출하여 세포질에서 작용하거나 핵으로 이동할 수 있어야 하므로, 엔도좀 탈출효율은 약물전달 시스템의 성능을 평가하는 중요한 지표이다.</span></span></span></span></span></span></span></span></span><br><p data-start="439" data-end="659"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">본 특허 기술은 약물전달입자의 엔도좀 탈출효율을 자기공명영상 기반으로 정량적으로 분석하는 방법에 관한 것이다. 구체적으로, 산화철 담지 입자를 섭취한 세포 또는 조직에 자기공명영상 장치를 이용하여 전자기파를 조사하고, 이때 반향되는 자기공명신호(MR signal)를 측정한다. 이후 시간 경과에 따른 자기이완율의 변화율을 분석함으로써 약물전달입자의 엔도좀 탈출효율을 정량적으로 평가할 수 있다.</span></span><br /><br /></span></span></span></span></span></span></span><br><p data-start="661" data-end="785"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">본 기술은 다양한 나노약물전달체의 세포 내 전달 성능을 정량적으로 평가할 수 있는 분석 플랫폼으로서, 향후 LNP, 리포좀 및 기타 나노전달체 기반 치료제 개발 과정에서 중요한 평가 기술로 활용될 수 있을 것으로 기대된다.</span></span></span></span></span></span></span></span></span><br><p data-start="661" data-end="785"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><br /></span></span></span><br><p data-start="787" data-end="982"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">The technology </span></span></span></span></span></span></span></span></span><span data-start="802" data-end="931"><span style="font-weight: bold; font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">“</span></span></span></span></span></span></span></span></span><span data-start="80" data-end="209" style="font-size: 9pt;"><span style="font-size: 8pt;"><span style="font-family: 돋움, dotum;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><b><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">Method for Analyzing Endosomal Escape Efficiency of Drug Delivery Particles</span></span></span></span></b></span></span></span></span></span></span><span style="font-weight: bold; font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">”</span></span></span></span></span></span></span></span></span></span><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;"> by Somin Lee has been registered as a U.S. patent.</span></span></span></span></span></span></span></span></span><br><p data-start="787" data-end="982"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><br /></span></span></span></span></span></span></span><br><p data-start="984" data-end="1469"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">Drug delivery particles, such as lipid nanoparticles (LNPs) and liposomes, are internalized into cells through the formation of intracellular organelles known as endosomes. For the efficient delivery and biological function of encapsulated materials, the particles or their cargo must escape from endosomes and either act in the cytoplasm or migrate to the nucleus. Therefore, endosomal escape efficiency is a critical parameter for evaluating the performance of drug delivery systems.</span></span></span></span></span></span></span></span></span><br><p data-start="1471" data-end="2015"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">This patented technology provides a quantitative method for analyzing the endosomal escape efficiency of drug delivery particles using magnetic resonance-based measurements. Specifically, cells or tissues that have taken up iron oxide-loaded particles are exposed to electromagnetic waves using a magnetic resonance imaging system, and the reflected magnetic resonance signal is measured. By analyzing changes in the magnetic relaxation rate over time, the endosomal escape efficiency of drug delivery particles can be quantitatively evaluated.</span></span><br /><br /></span></span></span></span></span></span></span><br><p data-start="2017" data-end="2298" data-is-last-node="" data-is-only-node=""><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-family: Arial;"><span style="font-family: Arial;"><span style="font-size: 8pt;"><span style="font-size: 9pt;"><span style="font-family: Arial;"><span style="font-size: 9pt;"><span style="font-size: 10pt;">This technology offers a quantitative analytical platform for assessing the intracellular delivery performance of various nanomedicine systems and is expected to serve as an important evaluation tool in the development of LNP-, liposome-, and other nanoparticle-based therapeutics.</span></span></span></span></span></span></span></span></span><br>